Vacancies
4 Post Doctoral PositionsInformal inquiries can be sent to Prof Giuseppe Battaglia g.battaglia@ucl.ac.uk
Note applications will not be accepted by email, please apply via following the link in each advert. See UCL Jobs pages Cellular targeting and trafficking
Research areas: Synthetic virology, Endocytosis, Live cell imaging ,3D Tissue models,Nano-Neurology and Nano-Oncology
We are looking for an individual to work on the design and characterisation of multiplexed nanoparticles to target brain tumours. The work will involve the design of polymersomes bearing multiple ligands and their interaction with living cells. We are interested in establishing single-cell based protocols to correlate multiplexing and multivalency with endocytosis, cellular trafficking, and transcytosis efficiency. Both of these will be studied in glioma and brain endothelial cells. The postholder will be required to carry out research into studying the targeting and trafficking of personalised polymersomes into both blood-brain barrier and glioma cells.The appointment is funded by the EPSRC for 3 years initially. The successful candidate will have a proven track record in cell trafficking and endocytosis with experience in advanced imaging techniques and imaging analysis. Experience with nanomaterials, brain tumour, and blood-brain barrier models is desirable but not essential. The appointee will have a PhD (or be near to being awarded a PhD) in Physical Biology, Cell Biophysics, Biological Physics or relevant discipline. We will accept applications from both life and physical scientists as long as they fulfil the essential requirements discussed above. The candidate must demonstrate their contribution to the scientific community, in the form of an appropriate number of publications in prestigious journals, patents, and conferences. Personalised Nanomedicine
Research areas: 3D Tissue models,Nano-Neurology and Nano-Oncology
We are seeking an individual to work on the characterisation polymersomes for therapeutic and diagnostic applications. The project is part of a multidisciplinary effort aimed toward the design of a multiplexed biodegradable carrier with characteristics suitable for clinical translation for the treatment of brain tumours. This will involve collaboration with clinicians, physical biologists, and physicists. The postholder will be required to carry out research into studying the targeting and trafficking of personalised polymersomes into both blood-brain barrier and glioma cells. The appointment is funded by the EPSRC for 3 years initially. The successful candidate will have experience in handling, culturing and characterising induced pluripotent stem (IPS) cells to engineer 3D models of glioma and blood brain barrier (BBB). They will have a proven track record in stem cell biology and experience in reprogramming cells into IPS and differentiating them into desired cells. Experience with nanomaterials, BBB models and glioma is desirable. The appointee will have a PhD (or be near to being awarded a PhD) in Cancer Biology, Neuroscience, Neuro-Oncology or relevant discipline, and advanced knowledge of neuro-physiology or glioma biology. We will accept applications from both life and physical scientists as long as they fulfil the essential requirements discussed above. The candidate must demonstrate their contribution to the scientific community in the form of an appropriate number of publications in prestigious journals, patents, and conferences. The Physics of chemotactic vesicles
Research areas: Supramolecular Engineering, Active vesicles and Reactive vesicles
We are looking for an individual to ork on the characterisation of polymersomes for therapeutic and diagnostic applications. This will involve the setting up of advance optical imaging techniques to track nanoparticle propulsion as well as the development of theoretical models to elucidate chemotaxis mechanisms. The project is part of a multidisciplinary effort aimed toward the design of multiplexed chemotactic carriers able to follow glucose gradient with characteristics suitable for clinical translation for the treatment of brain tumours. This will involve collaboration with clinicians, physical biologists, and physicists. The postholder will be required to carry out research into studying the targeting and trafficking of personalised polymersomes into both blood-brain barrier and glioma cells.The appointment is funded by the ERC for 3 years initially. The successful candidate will hold a PhD (or near to being awarded a PhD) in Soft Matter Physics, Advanced Optics, Photonics, Chemical Engineering, Bioengineering or a relevant discipline. Experience with either optical microscopy or soft matter physics is essential. Experience in active matter is desirable but not essential. We will accept applications from both engineers and physical scientists as long as they fulfil the essential requirements discussed above. The candidate must demonstrate their contribution to the scientific community, in the form of an appropriate number of publications in prestigious journals, patents, and conferences. MOLECULAR ENGINEERING of CHemotactic vesicles
Research areas: Supramolecular Engineering, Active vesicles and Reactive vesicles
We are looking for an individual to work on the characterisation of polymersomes for therapeutic and diagnostic applications. The project is part of a multidisciplinary effort aimed toward the design of multiplexed chemotactic carriers able to follow glucose gradient with characteristics suitable for clinical translation for the treatment of brain tumours. This will involve collaboration with clinicians, physical biologists, and physicists.The project will involve extensive cryogenic and conventional transmission electron microscopy and the synthesis of polymeric nanomaterials. The postholder will work on the design of chemotactic vesicles using both block copolymers, proteins and DNA nanopores. The postholder will be required to carry out research into studying the targeting and trafficking of personalised polymersomes into both blood brain barrier and glioma cells. The appointment is funded by the ERC for 3 years initially.The successful candidate will have a proven track record in extensive cryogenic and conventional transmission electron microscopy and the synthesis of polymeric nanomaterials. Experience of working with vesicles is desirable. The appointee will have a PhD (or near to being awarded a PhD) in Polymer science, Soft Matter Physics, Physical Chemistry, Chemical Engineering or relevant discipline. The candidate must demonstrate their contribution to the scientific community, in the form of an appropriate number of publications in prestigious journals, patents, and conferences. |
4 PhD StudentshipsApplications will be accepted until 30 June 2018 but the positions will be filled as soon as suitable candidates have been identified.
Please send your CV and relevant information to Prof Giuseppe Battaglia g.battaglia@ucl.ac.uk PhD in Bioinspired Phototactic nanorobots
Position 1: PhD position in Bionic Nanoscience Research areas: Active vesicles and Reactive vesicles Application deadline: 30 June 2018 Start date: 24 September 2018 Subject areas (Physics, Engineering, Soft Matter, Soft Robotics, and Physical Chemistry) A fully funded PhD studentship to work on the development of nanoscopic robots capable of autonomous movement driven by visible light. The general aim of the project is to design nanoscopic and soft robots able to navigate biological media to localise, pick up and deliver several types of molecular cargos including drugs and diagnostic probes. The system will be based on the synthetic vesicle technology developed within the Molecular Bionics laboratory led by Prof Giuseppe Battaglia. The project will be developed in collaboration with the Active Nano-Systems Laboratory led by Dr Giorgio Volpe (also at UCL) and will involve the design of plasmonic activated nanoreactors. We are looking for self-motivated and ambitious candidates who have (or will have by Sept 2018) a Master level degree in Physical Sciences or Engineering e.g. Physical Chemistry, Physics, Materials Science, or Chemical Engineering. Please note that UCL programmes and scholarships encourage students to look beyond the boundaries of their chosen discipline, as well as sharing and broadening knowledge across disciplines through societies and competitions. This means that the PhD title will be decided based on the project contents rather that the host department. We seek candidates keen to work at the interface between nano- and bio-physics. Previous experience in soft materials, plasmonics, or photonics is desirable but not essential as training will be provided. The scholarship is only open to candidates who fulfil the EPSRC student eligibility requirements (i.e. EU citizen with at least 3yrs of residence in the UK). Please send an up-to-date CV and motivation letter to g.battaglia@ucl.ac.uk and g.volpe@ucl.ac.uk 4-year EngD in Cancer Immunotherapy
Research areas: NanoOncology and Nano-Immunology Application deadline: 30 June 2018 Start date: 24 September 2018 Subject areas (Nanomedicine, cancer, and immunology) The UCL Centre for Doctoral Training in Molecular Modelling and Materials Science is offering a fully funded studentship to a highly motivated candidate to start in September 2018. The studentship will cover tuition fees at UK/EU rate plus a maintenance stipend £18550 (tax free) for four years. The project will be in collaboration with BTG plc. The student will carry out his/her doctoral research at UCL and also have the opportunity for work placements The project will involve the development of novel nanoparticle to deliver immunomodulator agents to cancer cells to elicit the appropriate immunological response to eradicate the tumour. The student will be trained in the design and characterisation of polymersomes (also polymer vesicles) able to target immune-cells associated with the tumour environment. Interested candidates should contact Prof Giuseppe Battaglia (g.battaglia@ucl.ac.uk) with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged. The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in biomedical science, immunology , molecular biology or equivalent. We also invite candidates with degree in Physics, Chemistry or Engineering who seeks experiences in the life sciences. Adequate training will be provided. Due to funding restrictions, this studentship is only open to applicants from the UK and EU, who have been resident in the UK for at least 3 years preceding their start on the programme or have indefinite leave to remain in the UK. . Applications will be accepted until 30 June 2018 but the position will be filled as soon as a suitable candidate has been identified. PhD in Combinatorial personalised Nanomedicine
Research areas: NanoOncology, Supramolecular Engineering , and Live cell imaging Application deadline: 30 June 2018 Start date: 24 September 2018 Subject areas (Nanomedicine, automation, drug delivery, and high content imaging) We are looking for a student to work along side two PDRAs and the spin-off company SomaNautix to develop personalised nanomedicines for the treatment of brain tumours. The student will be trained in the design and characterisation of polymersomes (also polymer vesicles) able to able to cross the blood brain barrier and to target glioma cells. In particular, the project involves the design and testing of automated liquid handling units to produce hundred-strong libraries of targeting polymersomes and drug-loaded polymersomes. These will be then tested using automated high content imaging to assess (i) cancer selectivity and (ii) personalised therapy. Interested candidates should contact Prof Giuseppe Battaglia (g.battaglia@ucl.ac.uk ) with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged. The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in Chemical Engineering, Mechanical Engineering , Bioengineering or equivalent. Due to funding restrictions, this studentship is only open to applicants from the UK and EU, who have been resident in the UK for at least 3 years preceding their start on the programme or have indefinite leave to remain in the UK. Applications will be accepted until 30 June 2018 but the position will be filled as soon as a suitable candidate has been identified. PhD in CHemotactic drug delivery Modelling
Research areas: Active vesicles and Physical Biology Application deadline: 30 June 2018 Start date: 24 September 2018 Subject areas (Computational Fluid Dynamics, Active Matter, Modelling) A fully sponsored studentship to work on the modelling of the diffusion and penetration of chemotactic polymersomes in different organs using both computational fluid dynamics and brownian dynamics algorithms. The project will involve both the development of theoretical model of chemotaxis as well as their implementation in realistic physiological scenarios. Interested candidates should contact Prof Giuseppe Battaglia (g.battaglia@ucl.ac.uk ) with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged. The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in Physics, Chemical Engineering, Mechanical Engineering , Bioengineering or equivalent. Due to funding restrictions, this studentship is open to applicants from the UK and EU, but funding limitations restricts it from overseas applicant unless match-funding is provided to make up for the excess fees. Applications will be accepted until 30 June 2018 but the position will be filled as soon as a suitable candidate has been identified. |
Interested in a post-doctoral fellowship
We welcome self-motivated and creative individuals with skills relevant (or not) to our research activities who wants apply for an independent fellowship. Please send us your CV, one page explaining your research project and two academic references. We will get back to you soon after and discuss possibilities. Meanwhile, have a look at the possible schemes
Interested in a Ph'D with us
We welcome talented and motivated individuals to undertake their doctoral studies within our group. Please check the UCL web pages for a comprehensive list of possible scholarships. If you have already secured your scholarship, or you need our support to do so, please send us your CV and one page of research statement and will get back to you soon after.
Who we areWe are chemists, physicists, physical chemists, biochemists, cell biologists, biomedical scientists, biotechnologists, chemical engineers, pharmacists, molecular engineers, robotic engineers, neurologists, immunologists, theoretical physicists, dentists, material scientists and biomedical engineers coming from many countries who share the need to have fun with science and as it happens to make incredible discoveries!
Here are few mementos from the Battaglia Research Group |
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