"Seeing is believing" is one the most essential axiom in science. Among the different tools to our disposal, microscopes whether optical or electron are the most used. We look at our materials with unprecedented details, how they interact with living cells and tissues and even use them to look at cells with new probing abilities. Our frontier in microscopy, whether optical or electron, is time. We're advancing new methods for liquid-phase transmission electron microscopy. We set up one of the first facilities dedicated to video-rate imaging of liquid samples with a sub-nanometer resolution. We look at both liquid biological and synthetic matter gathering its four-dimensional evolution. At the same time, we're adapting established optical techniques for fluorescence imaging to capture nanoseconds dynamics. Finally, in collaboration with synthetic inorganic chemists, we are developing new molecular probes that allow multimodal microscopy techniques combining fluorescence with heavy-metal contrast.