Infection and immunological disorders are a continuous burden and in the develping world, they still stand as number one killer. From one side, antibiotic development is experiencing a new era due to the emergence of drug resistance and, consequently the ability of delivering antibiotic becomes equally enabling. We have thus used our intracellular delivery polymersomes to tackle one of the most difficult infection to eradicate those caused by intracellular pathogens, including, s.aurus, m.tuberculosis, p.gingivitis and protozoic Leishmania. We have shown we can use this strategy to sterilise infected cells showing considerable improvement compared to free drugs [65, 66]. In collaboration with several laboratories expert in bacteria infection, including Simon Forster and Steven Renshaw (Sheffield), Timothy McHugh (UCL) we are expanding our efforts to several diseases. Alongside, we have also developed strategies for the delivery of immunomodulator agents including anti-inflammatory agents, again targeted delivery shows considerable augment over the naked drug.
- J. Robertsons, G. Battaglia* and S.Renshaw* Targeting Neutrophilic Inflammation using Polymersome-mediated Cellular Delivery J. Immunol. 2017 in the press
- J. D Robertson, G. Yealland, M. Avila-Olias, L. Chierico, O. Bandman, S. A Renshaw, G. Battaglia* pH-sensitive tubular polymersomes: formation and applications in cellular delivery ACS Nano, 2014, 8, 4650–4661
- K. Wayakanon, M. H Thornhill, I. Douglas, N.J. Warren, S. P. Armes, G. Battaglia* and C. Murdoch* Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells FASEB J., 2013 ,11, 4455-65
- I. Canton, M. Massignani, N. Patikarnmonthon, L. Chierico, J. Robertson, S. A. Renshaw, N. J. Warren, J. P. Madsen, S. P. Armes, A. L. Lewis, G. Battaglia* Fully synthetic polymer vesicles for intracellular delivery of antibodies in live cells FASEB J. 2013, 1 , 98-108.