Accessing our body is not a trivial task, and in order to reach the desired part, the carrier has to "navigate the body", and we call this Somanautics (from Greek: Sôma: Body -and Nautikos -navigation). The biological environment where the somanaut has to go through is the result of a hierarchical and intricate organisation of molecules, into macromolecules into supramolecular structures, into living cells, into tissues, into organs. Such complexity requires a systematic approach, and we are engaging this both at each level as well as holistically to understand the different aspects required for efficient navigation. At the molecular level, we aim to design systems that have limited interaction with soluble proteins so to prevent unspecific protein fouling and opsonisation. At the cellular level, we study the interaction between synthetic materials and cells (see endocytosis). At the tissue level, we have discovered that efficient transport is related to the carrier mechanical properties and its ability to "squeeze" through the narrow paracellular space combining translocation with size-exclusion percolation. At the physiological level, we are studying how synthetic carrier interacts with the immune system, move in and out of the vasculature, access specific organs. To this respect, we are now investigating new ways to control cellular selectivity and to follow endogenous chemical signalling using chemotaxis.